Sodium carboxymethyl cellulose (Sodium CMC, CMC-Na) has the advantages of non-toxicity, biocompatibility and good film forming properties and has been widely used as excipient in the pharmaceutical industry.
Excipients are traditionally considered as “inert carriers” (inactive carriers). However, excipients are not completely inert. Interactions between many excipients and active pharmaceutical ingredients (API) can affect the safety and efficacy of the product. And excipients may account for 1%~99% of the total preparation quality. Therefore, excipients are of great significance to the quality of preparations. Sodium CMC is one of the most widely used cellulose ethers in the world today, with high biocompatibility, biodegradation and low immunogenicity. Below are some of the applications of Sodium CMC in the pharmaceutical industry:
The dosage of tablet adhesive is 1.0%~6.0%, film coating material is 2%~5%, gel agent is 3.0%~6.0%, oral liquid is 0.1%~1%, injection is 0.05%~0.75%, and emulsifier is 0.25%~1.0%.
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