The Usage of CMC in Oilfield Industry
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Sodium carboxymethyl cellulose (Sodium CMC, CMC-Na) has the advantages of non-toxicity, biocompatibility and good film forming properties and has been widely used as excipient in the pharmaceutical industry.
Excipients are traditionally considered as “inert carriers” (inactive carriers). However, excipients are not completely inert. Interactions between many excipients and active pharmaceutical ingredients (API) can affect the safety and efficacy of the product. And excipients may account for 1%~99% of the total preparation quality. Therefore, excipients are of great significance to the quality of preparations. Sodium CMC is one of the most widely used cellulose ethers in the world today, with high biocompatibility, biodegradation and low immunogenicity. Below are some of the applications of Sodium CMC in the pharmaceutical industry:
- It can be used as a binder for solid preparations and low viscosity CMC is often used for this application.
- It can be used as water retention agent and dispersant of ointment drugs.
- It can be used as suspension, thickening and sticking-enhancing agent for liquid preparations like medicine pulp.
- It can be used as a film-forming material and water-soluble matrix.
- It can also be used as emulsifying agent for injection.
- It can also be used as a sustained-release skeleton tablet and a sustained-release drug film agent material in slow-release preparations. CMC is prepared into gel carrier. The drug can be controlled and released by gel swelling and shrinking. High viscosity CMC can be used for hydrophilic gel matrix tablets, which can be combined with hydroxypropyl methylcellulose to control drug release.
The dosage of tablet adhesive is 1.0%~6.0%, film coating material is 2%~5%, gel agent is 3.0%~6.0%, oral liquid is 0.1%~1%, injection is 0.05%~0.75%, and emulsifier is 0.25%~1.0%.
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